Discovery of potent cyclic pseudopeptide human tachykinin NK-2 receptor antagonists

J Med Chem. 2000 Nov 2;43(22):4041-4. doi: 10.1021/jm0010217.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CHO Cells
  • Cricetinae
  • Humans
  • In Vitro Techniques
  • Models, Molecular
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / physiology
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / metabolism
  • Point Mutation
  • Pulmonary Artery / drug effects
  • Pulmonary Artery / physiology
  • Rabbits
  • Radioligand Assay
  • Receptors, Neurokinin-2 / antagonists & inhibitors*
  • Receptors, Neurokinin-2 / metabolism
  • Structure-Activity Relationship

Substances

  • MEN 11420
  • Peptides, Cyclic
  • Receptors, Neurokinin-2
  • MEN 10627